Single-channel Pilot-type Automatic Peptide Synthesizer

Single-channel Pilot-type Automatic Peptide Synthesizer

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DL-PSI-486 Single-channel Pilot-type Automatic Peptide Synthesizer
PSI486 single-channel pilot-type fully automatic peptide synthesis instrument is a standing solid-phase peptide synthesis instrument for pilot-scale production of peptides. Fully automated greatly saves labourcost, only need to set the order of amino acidaddition, time duration, etc. in the software, and then the synthesis can be started automatically according to the program. Nitrogen/solvent is alternated periodically to clean the pipeline automatically.
After the peptide chain is developed and screened in the laboratory, the second step is "small test", i.e. to amplify according to the laboratory results; the third step is "pilot test", i.e. to continue to amplify according to the results of thesmall test, and the target peptide chain can be mass-produced basically after the success ofthe pilot test. The PSI486 single-channel pilot-type fully automated peptide synthesis instrument was specially developed for the needs of the pilot test. PSI486 single-channel pilot-type automatic peptide synthesis instrument adopts single-channel, single reactor synthesis scale is 2.5-20mmol; 6 amino acid tanks are convenient for users to customise a variety of amino acids, coupling agents, side chain groups, etc.; 7 solvent tanks can be placed in different commonly used solvents for washing, it is the standing solid-phase peptide synthesizer for the production of peptides on a pilot scale. The peptide synthesis instrument of American Peptide Technology Company adopts the mixing mode of
"fixed reactor, stirring paddle pushing the solid-phase resin to collide with the reactants"; when the stirring paddleis activated, the resin is grinded and squeczed, and part of the resin is deformed and broken, which reduces the coupling rate; and the broken resin seeps into the gap of the sieve plate, which influences the speed of liquid discharging. In order to avoid resin damage, in 1995, JOHN YE successfully tested the mixing mode without stirring paddles, in which the solid-phase resin collides with the reactants by turning the reactor up and down, and the coupling efficiency increased to more than 99.5%.